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Structure of the quinolinate synthase Y107F variant in an empty open form

Analyse Structure of the quinolinate synthase Y107F variant in an empty open form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7P4M
Type: protein
Length: 303 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Quinolinate synthase a
EC: 2.5.1.72
UniProt: Q9X1X7
Ligands: SF4, F3S, CL
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Quinolinate synthase a (EC 2.5.1.72)	protein	303	49% helix, 16% strand	Q9X1X7

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · chains A
F3S · FE3-S4 cluster · ligand · chains A
CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	254	0.68	0.84	46	SF4, F3S, CL

Compared structures

7P4M · Structure of the quinolinate synthase Y107F variant in an empty open form · the same entry in another collection · chain A against A, TM-score 1.00
Q9X1X7 · AlphaFold monomer V2.0 prediction for quinolinate synthase a (Q9X1X7) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X1X7
Elsewhere: RCSB PDB 7P4M · PDBe 7P4M · UniProt Q9X1X7

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