UniProt Q9X1X7
Quinolinate synthase A (Q9X1X7)
Quinolinate synthase A (UniProt Q9X1X7), EC 2.5.1.72: 28 experimental structures on GenesisL1, 17 ligands bound, 8 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9X1X7
- Protein
- Quinolinate synthase A
- EC
- 2.5.1.72
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 17
- Pockets
- 8 · 3 records with a druggable one
Structures
28 records of Q9X1X7 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4P3X | Structure of the Fe4S4 quinolinate synthase NadA from Thermotoga maritima | x-ray diffraction | A | — | — |
| 4P3X | Structure of the FE4S4 quinolinate synthase nada from thermotoga maritima | x-ray diffraction | A | — | — |
| 5F33 | Structure of quinolinate synthase in complex with phosphoglycolohydroxamate | x-ray diffraction | A | SF4, PGH, SO4 | 1 (best 0.72) |
| 5F33 | Structure of quinolinate synthase in complex with phosphoglycolohydroxamate | x-ray diffraction | A | — | — |
| 5F35 | Structure of quinolinate synthase in complex with citrate | x-ray diffraction | A | SF4, MG | — |
| 5F35 | Structure of quinolinate synthase in complex with citrate | x-ray diffraction | A | — | — |
| 5F3D | Structure of quinolinate synthase in complex with reaction intermediate W | x-ray diffraction | A | SF4, 5UK, SO4 | — |
| 5F3D | Structure of quinolinate synthase in complex with reaction intermediate W | x-ray diffraction | A | — | — |
| 5LQM | Structure of quinolinate synthase Y21F mutant in complex with citrate | x-ray diffraction | A | SF4 | — |
| 5LQM | Structure of quinolinate synthase Y21F mutant in complex with citrate | x-ray diffraction | A | SF4 | — |
| 5LQS | Structure of quinolinate synthase Y21F mutant in complex with substrate-derived quinolinate | x-ray diffraction | A | SF4, NTM, CL | — |
| 5LQS | Structure of quinolinate synthase Y21F mutant in complex with substrate-derived quinolinate | x-ray diffraction | A | SF4, NTM, CL | — |
| 6F48 | Structure of quinolinate synthase with reaction intermediates X and Y | x-ray diffraction | A | SF4, XQB, CL, YQA | — |
| 6F4D | Structure of the Y21F variant of quinolinate synthase in complex with pgh | x-ray diffraction | A | SF4, PGH, PO4, CL | — |
| 6F4L | Structure of quinolinate synthase with inhibitor-derived quinolinate | x-ray diffraction | A | SF4, NTM, CL | — |
| 6G74 | Structure of the Y21F variant of quinolinate synthase in complex with phthalate | x-ray diffraction | A, B | SF4, PHT | 6 (best 0.73) |
| 6G74 | Structure of the Y21F variant of quinolinate synthase in complex with phthalate | x-ray diffraction | A, B | SF4, PHT | — |
| 6I0K | Structure of quinolinate synthase in complex with 4-mercaptophthalic acid | x-ray diffraction | A | SF4, GZ8, PO4, CL | — |
| 6I0K | Structure of quinolinate synthase in complex with 4-mercaptophthalic acid | x-ray diffraction | A | SF4, GZ8, PO4, CL | — |
| 6I0P | Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid | x-ray diffraction | A | SF4, QAS, CL, PO4 | — |
| 6I0P | Structure of quinolinate synthase in complex with 6-mercaptopyridine- 2,3-dicarboxylic acid | x-ray diffraction | A | SF4, QAS, CL, PO4 | — |
| 6I0R | Structure of quinolinate synthase in complex with 5-mercaptopyridine-2,3-dicarboxylic acid | x-ray diffraction | A | FE, H2S, QAT | — |
| 6I0R | Structure of quinolinate synthase in complex with 5-mercaptopyridine- 2,3-dicarboxylic acid | x-ray diffraction | A | FE, H2S, QAT | — |
| 7P4M | Structure of the quinolinate synthase Y107F variant in an empty open form | x-ray diffraction | A | SF4, F3S, CL | — |
| 7P4P | Structure of the quinolinate synthase A84L variant complexed with citrate | x-ray diffraction | A | SF4, MG, CL | 1 (best 0.74) |
| 7P4P | Structure of the quinolinate synthase A84L variant complexed with citrate | x-ray diffraction | A | SF4, MG, CL | — |
| 7P4Q | Structure of the quinolinate synthase S124A variant complexed with citrate | x-ray diffraction | A | SF4, F3S, CL | — |
| Q9X1X7 | AlphaFold monomer V2.0 prediction for quinolinate synthase a (Q9X1X7) | — | — | — |
Ligands
- SF4 · Iron/sulfur cluster · in 20 records
- CL · Chloride ion · in 13 records
- PO4 · Phosphate ion · in 5 records
- MG · Magnesium ion · in 3 records
- NTM · Quinolinic acid · in 3 records
- F3S · FE3-S4 cluster · in 2 records
- FE · Fe (III) ion · in 2 records
- GZ8 · 4-mercaptoidenecyclohexa-2,5-diene-1,2-dicarboxylic acid · in 2 records
- H2S · Hydrosulfuric acid · in 2 records
- PGH · Phosphoglycolohydroxamic acid · in 2 records
- PHT · Phthalic acid · in 2 records
- QAS · 6-mercaptopyridine-2,3-dicarboxylic acid · in 2 records
- QAT · 5-mercaptopyridine-2,3-dicarboxylic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- 5UK · 2-imino,3-carboxy,5-oxo,6-hydroxy hexanoic acid · in 1 record
- XQB · 2-imino,3-carboxy,5-hydroxy,6-oxo hexanoic acid · in 1 record
- YQA · 5-hydroxy,-4,5-dihydroquinolinate · in 1 record
Elsewhere
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