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Crystal structure of human MARC1 A165T variant
Analyse Crystal structure of human MARC1 A165T variant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7P41
- Type
- protein
- Length
- 444 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial amidoxime-reducing component 1,ENDOLYSIN, mitochondrial amidoxime-reducing…
- EC
- 1.7.-.-, 3.2.1.17
- UniProt
- Q5VT66, D9IEF7
- Ligands
- EFK, MTE, CL
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Mitochondrial amidoxime-reducing component 1,ENDOLYSIN, mitochondrial amidoxime-reducing component 1 (EC 1.7.-.-, 3.2.1.17) | protein | 444 | 34% helix, 28% strand | Q5VT66, D9IEF7 |
Ligands and binding sites
- EFK · oxidanyl(oxidanylidene)molybdenum · ligand · chains D
- MTE · Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester · ligand · chains D
- CL · Chloride ion · ion · chains D
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.66 | 0.86 | 30 | EFK, MTE |
| 2 | 385 | 0.62 | 0.77 | 51 | empty |
| 3 | 165 | 0.43 | 0.74 | 25 | B3P |
| 4 | 86 | 0.34 | 0.74 | 18 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5VT66
- Every structure of UniProt D9IEF7
- Elsewhere: RCSB PDB 7P41 · PDBe 7P41 · UniProt Q5VT66 · UniProt D9IEF7
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