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Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA in complex with fragment 166 at the transient P-pocket.
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- PDB
- 7OZ5
- Type
- protein + DNA
- Length
- 2,017 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03366
- Ligands
- 3IR, GLC, FRU, CD
Structure
x-ray diffraction · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 555 | — | P03366 |
| B | — | protein | 418 | — | P03366 |
| T | — | dna | 24 | — | — |
| P | — | dna | 21 | — | — |
| C | — | protein | 551 | — | P03366 |
| D | — | protein | 406 | — | P03366 |
| E | — | dna | 22 | — | — |
| F | — | dna | 20 | — | — |
Ligands and binding sites
- 3IR · (1~{R},2~{R})-2-phenyl-~{N}-(1,3-thiazol-2-yl) cyclopropane-1-carboxamide · ligand · chains C, E, F
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains B, D
- FRU · beta-D-fructofuranose · sugar · 2 copies · chains B, D
- CD · Cadmium ion · metal · 18 copies · chains A, B, T, P, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7OZ5 · Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA in complex… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 7OZ5 · PDBe 7OZ5 · UniProt P03366
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