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E3 ring ligase binding domain

Analyse E3 ring ligase binding domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7OVX
Type: protein
Length: 186 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase TRIM7; Peptide G
EC: 2.3.2.27
UniProt: Q9C029
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27)	protein	174	3% helix, 43% strand	Q9C029
Q	Peptide G	protein	12	67% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.30	0.73	16	empty

Interfaces

1 interface between chains.

A–Q · 490 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7OVX · E3 RING ligase binding domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9C029 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM7 (Q9C029) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9C029
Elsewhere: RCSB PDB 7OVX · PDBe 7OVX · UniProt Q9C029

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