Research workbench
The refined 2.0 ångströms X-ray crystal structure of the complex formed between bovine beta-trypsin and cmti-I, a trypsin inhibitor from squash seeds (cucurbita maxima): topological similarity of the squash seed inhibitors with the carboxypeptidase a inhibitor from potatoes
Analyse The refined 2.0 ångströms X-ray crystal structure of the complex formed between… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1PPE
- Type
- protein
- Length
- 252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trypsin; Trypsin inhibitor cmti-I
- EC
- 3.4.21.4
- UniProt
- P00760, P01074
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Trypsin (EC 3.4.21.4) | protein | 223 | 10% helix, 35% strand | P00760 |
| I | Trypsin inhibitor cmti-I | protein | 29 | 10% helix, 21% strand | P01074 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.35 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- E–I · 867 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 1PPE · The refined 2.0 ångströms X-ray crystal structure of the complex formed between bovine… · the same entry in another collection · chain E against E, TM-score 1.00
- P01074 · AlphaFold monomer V2.0 prediction for trypsin inhibitor 1 (P01074) · a predicted model of the same protein · chain I against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00760
- Every structure of UniProt P01074
- Elsewhere: RCSB PDB 1PPE · PDBe 1PPE · UniProt P00760 · UniProt P01074
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.