Ternary complex of 14-3-3 sigma, NOTCHPS1917 phosphopeptide, and WQ136

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 0AW · ~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-2,3-dihydro-1-benzofuran-5-carboxamide · ligand · 3 copies · chains A, B
• MG · Magnesium ion · metal · chains A
• CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7OR3 · Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136 · the same entry in another collection · chain A against A, TM-score 1.00
• P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q99466 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 4 (Q99466) · a predicted model of the same protein · chain B against A, TM-score 0.56

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P31947
• Every structure of UniProt Q99466
• Elsewhere: RCSB PDB 7OR3 · PDBe 7OR3 · UniProt P31947 · UniProt Q99466