Research workbench
RSK2 N-terminal kinase domain in complex with ORF45
Analyse RSK2 N-terminal kinase domain in complex with ORF45 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OPO
- Type
- protein
- Length
- 2,046 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal protein S6 kinase alpha-3; Protein ORF45
- EC
- 2.7.11.1
- UniProt
- P51812, F5HDE4
- Ligands
- ANP
- Pockets
- 17 · best druggability 0.87
Structure
x-ray diffraction · 9 distinct chains · 30% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) | protein | 295 | 34% helix, 24% strand | P51812 |
| B, D | Protein ORF45 | protein | 47 | 0% helix, 13% strand | F5HDE4 |
| C | Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) | protein | 295 | 34% helix, 24% strand | P51812 |
| E, K | Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) | protein | 293 | 34% helix, 23% strand | P51812 |
| F, L | Protein ORF45 | protein | 45 | 0% helix, 13% strand | F5HDE4 |
| G | Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) | protein | 301 | 33% helix, 23% strand | P51812 |
| H | Protein ORF45 | protein | 48 | 0% helix, 15% strand | F5HDE4 |
| I | Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) | protein | 292 | 32% helix, 25% strand | P51812 |
| J | Protein ORF45 | protein | 45 | 0% helix, 13% strand | F5HDE4 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 6 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 756 | 0.87 | 0.90 | 128 | ANP |
| 2 | 1015 | 0.87 | 0.88 | 125 | ANP |
| 3 | 1075 | 0.85 | 0.86 | 108 | ANP |
| 4 | 952 | 0.85 | 0.86 | 101 | ANP |
| 5 | 178 | 0.73 | 0.90 | 29 | ANP |
Interfaces
29 interfaces between chains.
- C–D · 2026 Ų buried · 27 hydrogen bonds · protein-protein
- G–H · 2006 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1948 Ų buried · 25 hydrogen bonds · protein-protein
- E–F · 1910 Ų buried · 23 hydrogen bonds · protein-protein
- K–L · 1897 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 7OPO · RSK2 N-terminal kinase domain in complex with ORF45 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51812
- Every structure of UniProt F5HDE4
- Elsewhere: RCSB PDB 7OPO · PDBe 7OPO · UniProt P51812 · UniProt F5HDE4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.