UniProt P51812
Ribosomal protein S6 kinase alpha-3 (P51812)
Ribosomal protein S6 kinase alpha-3 (UniProt P51812), EC 2.7.11.1: 25 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P51812
- Protein
- Ribosomal protein S6 kinase alpha-3
- EC
- 2.7.11.1
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 35 · 6 records with a druggable one
Structures
26 records of P51812 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D9T | Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl… | x-ray diffraction | A | — | — |
| 4D9T | RSK2 C-terminal kinase domain with inhibitor (E)-methyl 3-(4-amino-7… | x-ray diffraction | A | — | — |
| 4D9U | Rsk2 C-terminal Kinase Domain, (E)-tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2… | x-ray diffraction | A | — | — |
| 4D9U | RSK2 C-terminal kinase domain, (E)-tert-butyl 3-(4-amino-7-(3… | x-ray diffraction | A | — | — |
| 4JG6 | RSK2 CTD bound to 2-cyano-3-(1H-indazol-5-yl)acrylamide | x-ray diffraction | A | — | — |
| 4JG6 | RSK2 ctd bound to 2-cyano-3-(1H-indazol-5-YL)ACRYLAMIDE | x-ray diffraction | A | — | — |
| 4JG7 | Structure of RSK2 CTD bound to 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyanoacrylamide | x-ray diffraction | A | — | — |
| 4JG7 | Structure of RSK2 ctd bound to 3-(3-(1H-PYRROLO[2,3-B]PYRIDINE-3- CARBONYL)PHENYL)-2-cyanoacrylamide | x-ray diffraction | A | — | — |
| 4JG8 | Structure of RSK2 T493M CTD mutant bound to 2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-tr… | x-ray diffraction | A | — | — |
| 4JG8 | Structure of RSK2 T493M ctd mutant bound to 2-cyano-N-(1-hydroxy-2… | x-ray diffraction | A | — | — |
| 4NUS | Rsk2 N-terminal kinase in complex with LJH685 | x-ray diffraction | A | — | — |
| 4NUS | RSK2 N-terminal kinase in complex with LJH685 | x-ray diffraction | A | — | — |
| 4NW5 | Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 | x-ray diffraction | A | — | — |
| 4NW5 | RSK2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 | x-ray diffraction | A | — | — |
| 4NW6 | Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27 | x-ray diffraction | A | — | — |
| 4NW6 | RSK2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27 | x-ray diffraction | A | — | — |
| 5D9K | Rsk2 N-terminal Kinase in Complex with BI-D1870 | x-ray diffraction | A, B | 584 | 3 (best 0.66) |
| 5D9K | RSK2 N-terminal kinase in complex with bi-D1870 | x-ray diffraction | A, B | — | — |
| 5D9L | Rsk2 N-terminal Kinase in Complex with bis-phenol pyrazole | x-ray diffraction | A | 583 | 3 (best 0.57) |
| 5D9L | RSK2 N-terminal kinase in complex with bis-phenol pyrazole | x-ray diffraction | A | — | — |
| 7OPO | RSK2 N-terminal kinase domain in complex with ORF45 | x-ray diffraction | A, C, E, G, I, K | ANP | — |
| 8EQ5 | Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160) | x-ray diffraction | A | QCT | 3 (best 0.64) |
| 8R58 | The RSK 2 N-terminal kinase domain in complex with BMF (1-19) | x-ray diffraction | A | QCT | 3 (best 0.65) |
| 8XEY | The Crystal Structure of C-terminal kinase domain of RSK2 from Biortus | x-ray diffraction | A | — | 3 (best 0.65) |
| 8XFY | The Crystal Structure of RSK2 from Biortus. | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | A1LU8 | 20 (best 0.65) |
| P51812 | AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase alpha-3 (P51812) | predicted | A | — | — |
Ligands
- QCT · 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside · in 2 records
- 583 · 4,4'-(1H-pyrazole-3,4-diyl)diphenol · in 1 record
- 584 · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one · in 1 record
- A1LU8 · 2,6-bis(fluoranyl)-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenol · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
Experiment against prediction
- 8XFY chain J against the predicted model P51812: TM-score 0.97, RMSD 1.06 Å
- 8XFY chain F against the predicted model P51812: TM-score 0.97, RMSD 1.07 Å
- 8XFY chain D against the predicted model P51812: TM-score 0.97, RMSD 1.12 Å
- 8XFY chain E against the predicted model P51812: TM-score 0.97, RMSD 1.14 Å
- 5D9K chain A against the predicted model P51812: TM-score 0.97, RMSD 1.28 Å
- 5D9K chain A against the predicted model P51812: TM-score 0.97, RMSD 1.28 Å
- 5D9K chain B against the predicted model P51812: TM-score 0.97, RMSD 1.33 Å
- 5D9K chain B against the predicted model P51812: TM-score 0.97, RMSD 1.33 Å
- 8XFY chain I against the predicted model P51812: TM-score 0.97, RMSD 1.17 Å
- 8XFY chain C against the predicted model P51812: TM-score 0.95, RMSD 1.57 Å
Elsewhere
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