GL1X · GenesisL1 explorer

Ligand · 584

584 · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one

584, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one (C19 H23 F2 N5 O2, 391.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site…

Component
584
Formula
C19 H23 F2 N5 O2
Class
ligand
Structures
3
PDB entries
2

Binding sites

584 in 3 structures; the first of them:

  • 5WIK · JAK2 Pseudokinase in complex with BI-D1870 · 584 B901 · binds LEU551, GLY552, GLN553, ILE559, LEU579, LYS581, VAL610, GLU627 and 7 more
  • 5WIK · JAK2 pseudokinase in complex with bi-D1870 · 584 B901 · binds LEU551, GLY552, GLN553, ILE559, LEU579, LYS581, VAL610, GLU627 and 7 more
  • 7N7L · Crystal structure of PI5P4KIIALPHA complex with bi-D1870 · 584 A501 · binds PHE134, ILE143, PRO176, THR196, ARG197, ASN198, VAL199, PHE200 and 6 more

Residues it binds most

LEU 3, ILE 3, LYS 3, VAL 3, GLY 2, PHE 3, SER 2, ASP 1, GLN 2, GLU 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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