Research workbench
Lassa virus L protein in a pre-initiation conformation [preinitiation]
Analyse Lassa virus L protein in a pre-initiation conformation [preinitiation] in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OJL
- Type
- protein + RNA
- Length
- 1,531 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; 3' RNA; 5' RNA
- EC
- 2.7.7.48, 3.1.-.-
- UniProt
- A0A3S8NV63
- Ligands
- MN
- Pockets
- 18 · best druggability 0.75
Structure
electron microscopy · 3 distinct chains · 50% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-) | protein | 1498 | 50% helix, 8% strand | A0A3S8NV63 |
| E | 3' RNA | rna | 13 | — | — |
| D | 5' RNA | rna | 20 | — | — |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.75 | 0.78 | 71 | empty |
| 2 | 788 | 0.73 | 0.79 | 81 | empty |
| 3 | 786 | 0.73 | 0.78 | 76 | empty |
| 4 | 945 | 0.73 | 0.77 | 72 | empty |
| 5 | 410 | 0.68 | 0.80 | 50 | empty |
Interfaces
3 interfaces between chains.
- L–D · 2059 Ų buried · 38 hydrogen bonds · protein-nucleic
- L–E · 1305 Ų buried · 38 hydrogen bonds · protein-nucleic
- E–D · 432 Ų buried · 29 hydrogen bonds · nucleic-nucleic
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7OJL · Lassa virus L protein in a pre-initiation conformation [PREINITIATION] · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3S8NV63
- Elsewhere: RCSB PDB 7OJL · PDBe 7OJL · UniProt A0A3S8NV63
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.