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Lassa virus L protein bound to 3' promoter RNA (well-resolved polymerase core) [3END-core]

Analyse Lassa virus L protein bound to 3' promoter RNA (well-resolved polymerase core)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7OEA
Type: protein + RNA
Length: 1,439 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase L; 3' vrna
EC: 2.7.7.48, 3.1.-.-
UniProt: A0A3S8NV63
Ligands: ZN, MG
Pockets: 20 · best druggability 0.71

Structure

electron microscopy · 2 distinct chains · 51% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-)	protein	1432	51% helix, 11% strand	A0A3S8NV63
E	3' vrna	rna	7	—	—

Ligands and binding sites

ZN · Zinc ion · metal · chains L
MG · Magnesium ion · metal · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	581	0.71	0.79	70	empty
2	600	0.69	0.78	53	empty
3	337	0.64	0.79	34	empty
4	265	0.61	0.80	38	empty
5	233	0.57	0.79	39	empty

Interfaces

1 interface between chains.

L–E · 1108 Å² buried · 23 hydrogen bonds · protein-nucleic

Compared structures

7OEA · Lassa virus L protein bound to 3' promoter RNA (well-resolved polymerase core) [3END-CORE] · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A3S8NV63
Elsewhere: RCSB PDB 7OEA · PDBe 7OEA · UniProt A0A3S8NV63

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