Research workbench
Lasb, alpha-alkyl-N-aryl mercaptoacetamide
Analyse Lasb, alpha-alkyl-N-aryl mercaptoacetamide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OC7
- Type
- protein
- Length
- 298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutral metalloproteinase
- EC
- 3.4.24.-
- UniProt
- Q3Y6H8
- Ligands
- V85, ZN, CA
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neutral metalloproteinase (EC 3.4.24.-) | protein | 298 | 40% helix, 15% strand | Q3Y6H8 |
Ligands and binding sites
- V85 · (2R)-N,3-diphenyl-2-sulfanyl-propanamide · ligand · chains A
- ZN · Zinc ion · metal · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 138 | 0.48 | 0.78 | 28 | ZN, V85 |
| 2 | 55 | 0.32 | 0.76 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7OC7 · LasB, alpha-alkyl-N-aryl mercaptoacetamide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3Y6H8
- Elsewhere: RCSB PDB 7OC7 · PDBe 7OC7 · UniProt Q3Y6H8
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