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Cryo-EM structure of respiratory complex I under turnover

Analyse Cryo-EM structure of respiratory complex I under turnover in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7O6Y
Type: protein
Length: 7,927 residues
Chains: 42
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q9UUU3, Q9UUU2, Q9UUU1, Q9UUU0, Q9UUT9, Q9UUT8, Q9UUT7, S5U4U1, Q6ZY23, Q6ZY24, S5U3V2, S5U4R9, S5TMS4, S5TMP9, S5TF58, S5U3X7, A0A1D8NJR0, A0A1D8NC63, A0A371BY45, A0A371C5F3, A0A371CB65, A0A1H6Q8Z5, A0A1H6PXT9, A0A1D8N3C8, A0A1D8NG21, A0A1D8NDL1, A0A371C2D0, A0A1H6PPE5, A0A1D8NKB4, A0A1D8N7X0, A0A1D8N3H5, A0A1D8ND94, A0A1D8NGI5, A0A371C0F2, A0A1D8N596, A0A1D8NFX6, A0A1H6PJS3, A0A1D8N5V2, A0A1H6Q311, A0A371CFV9, A0A1H6PKH9, A0A1D8NNZ0
Ligands: 3PE, SF4, PLC, CDL, T7X, FES, LMN, ZMP, FMN, NAI, UQ9, CPL, NDP, ZN

Structure

electron microscopy · 42 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	693	—	Q9UUU3
B	—	protein	457	—	Q9UUU2
C	—	protein	410	—	Q9UUU1
G	—	protein	239	—	Q9UUU0
H	—	protein	216	—	Q9UUT9
I	—	protein	190	—	Q9UUT8
K	—	protein	177	—	Q9UUT7
L	—	protein	86	—	S5U4U1
S	—	protein	182	—	Q6ZY23
j	—	protein	90	—	Q6ZY24
1	—	protein	340	—	S5U3V2
2	—	protein	469	—	S5U4R9
3	—	protein	117	—	S5TMS4
4	—	protein	481	—	S5TMP9
5	—	protein	648	—	S5TF58
6	—	protein	135	—	S5U3X7
g	—	protein	76	—	A0A1D8NJR0
D	—	protein	86	—	A0A1D8NC63
E	—	protein	334	—	A0A371BY45
F	—	protein	120	—	A0A371C5F3
J	—	protein	172	—	A0A371CB65
M	—	protein	117	—	A0A1H6Q8Z5
O	—	protein	71	—	A0A1H6PXT9
P	—	protein	123	—	A0A1D8N3C8
Q	—	protein	85	—	A0A1D8NG21
R	—	protein	106	—	A0A1D8NDL1
U	—	protein	171	—	A0A371C2D0
W	—	protein	121	—	A0A1H6PPE5
X	—	protein	164	—	A0A1D8NKB4
Y	—	protein	125	—	A0A1D8N7X0
Z	—	protein	181	—	A0A1D8N3H5
a	—	protein	124	—	A0A1D8ND94
b	—	protein	64	—	A0A1D8NGI5
c	—	protein	44	—	A0A371C0F2
d	—	protein	89	—	A0A1D8N596
e	—	protein	52	—	A0A1D8NFX6
f	—	protein	82	—	A0A1H6PJS3
h	—	protein	136	—	A0A1D8N5V2
i	—	protein	83	—	A0A1H6Q311
n	—	protein	114	—	A0A371CFV9
8	—	protein	71	—	A0A1H6PKH9
9	—	protein	86	—	A0A1D8NNZ0

Ligands and binding sites

3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 16 copies · chains C, I, 1, W, 3, E, U, 2, 4, b, S, 5, i, a, J, 6, D, g, K
SF4 · Iron/sulfur cluster · ligand · 6 copies · chains A, B, I, C, K
PLC · Diundecyl phosphatidyl choline · ligand · 6 copies · chains K, 1, h, g, W, C, 2, 4, 5, I, i, n
CDL · Cardiolipin · ligand · 6 copies · chains 2, g, X, 1, 3, E, I, W, 6, D, Z, h, S, 4, 5, i, n
T7X · Phosphatidylinositol · ligand · 3 copies · chains L, 2, 5, J, K, 1, 3, E, X, b
FES · Fe2/s2 (inorganic) cluster · ligand · 2 copies · chains A, H
LMN · Lauryl Maltose Neopentyl Glycol · ligand · 2 copies · chains 2, 4, J, j, a
ZMP · S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate · ligand · 2 copies · chains O, P, Q, R
FMN · Flavin mononucleotide · ligand · chains B
NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · chains B
UQ9 · Ubiquinone-9 · ligand · chains C, K
CPL · 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine · ligand · chains 2, b
NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains K, E
ZN · Zinc ion · metal · chains M

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7O6Y · Cryo-EM structure of respiratory complex I under turnover · the same entry in another collection · chain A against A, TM-score 1.00

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