Research workbench
Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody
Analyse Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O3B
- Type
- protein
- Length
- 709 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nanobody 36Z; Tau-tubulin kinase 2,CENTROSOMAL protein of 164 kda
- EC
- 2.7.11.1
- UniProt
- Q6IQ55, Q9UPV0
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 11% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nanobody 36Z | protein | 122 | 5% helix, 53% strand | — |
| B | Nanobody 36Z | protein | 124 | 5% helix, 52% strand | — |
| C | Nanobody 36Z | protein | 121 | 5% helix, 54% strand | — |
| G, H, I | Tau-tubulin kinase 2,CENTROSOMAL protein of 164 kda (EC 2.7.11.1) | protein | 114 | 31% helix, 18% strand | Q6IQ55, Q9UPV0 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 358 | 0.62 | 0.78 | 24 | empty |
| 2 | 403 | 0.61 | 0.77 | 29 | empty |
| 3 | 307 | 0.61 | 0.79 | 46 | empty |
| 4 | 338 | 0.60 | 0.77 | 25 | empty |
Interfaces
5 interfaces between chains.
- B–H · 1443 Ų buried · 26 hydrogen bonds · protein-protein
- C–I · 1406 Ų buried · 19 hydrogen bonds · protein-protein
- A–G · 1365 Ų buried · 24 hydrogen bonds · protein-protein
- B–G · 739 Ų buried · 9 hydrogen bonds · protein-protein
- G–I · 162 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7O3B · Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody · the same entry in another collection · chain I against I, TM-score 1.00
- Q9UPV0 · AlphaFold monomer V2.0 prediction for centrosomal protein of 164 kda (Q9UPV0) · a predicted model of the same protein · chain G against A, TM-score 0.77
- Q6IQ55 · AlphaFold monomer V2.0 prediction for tau-tubulin kinase 2 (Q6IQ55) · a predicted model of the same protein · chain G against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IQ55
- Every structure of UniProt Q9UPV0
- Elsewhere: RCSB PDB 7O3B · PDBe 7O3B · UniProt Q6IQ55 · UniProt Q9UPV0
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