UniProt Q6IQ55
Tau-tubulin kinase 2 (Q6IQ55)
Tau-tubulin kinase 2 (UniProt Q6IQ55), EC 2.7.11.1: 13 experimental structures on GenesisL1, 8 ligands bound, 29 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q6IQ55
- Protein
- Tau-tubulin kinase 2
- EC
- 2.7.11.1
- Experimental structures
- 13
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 29 · 6 records with a druggable one
Structures
13 records of Q6IQ55 in the MolNFT archive: 13 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6U0K | TTBK2 kinase domain in complex with Compound 1 | x-ray diffraction | B, A | PO4, DTQ | 5 (best 0.81) |
| 6U0K | TTBK2 kinase domain in complex with compound 1 | x-ray diffraction | B, A | PO4, DTQ | — |
| 6VRF | ADP bound TTBK2 kinase domain | x-ray diffraction | A, B | ADP, PO4, NA, MG | 4 (best 0.76) |
| 6VRF | ADP bound TTBK2 kinase domain | x-ray diffraction | A, B | ADP, PO4, NA, MG | — |
| 7O3B | Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody | x-ray diffraction | G, H, I | — | 4 (best 0.62) |
| 7O3B | Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody | x-ray diffraction | G, H, I | — | — |
| 7Q8Y | Crystal structure of TTBK2 in complex with VNG2.73 (compound 42) | x-ray diffraction | A, B | PO4, 9IV | 5 (best 0.66) |
| 7Q8Y | Crystal structure of TTBK2 in complex with VNG2.73 (compound 42) | x-ray diffraction | A, B | PO4, 9IV | — |
| 7Q8Z | Crystal structure of TTBK2 in complex with VNG1.33 (compound 27) | x-ray diffraction | A, B | PO4, 9IK | 6 (best 0.66) |
| 7Q8Z | Crystal structure of TTBK2 in complex with VNG1.33 (compound 27) | x-ray diffraction | A, B | PO4, 9IK | — |
| 7Q90 | Crystal structure of TTBK2 in complex with VNG1.63 (compound 32) | x-ray diffraction | A, B | PO4, 9IS | 5 (best 0.65) |
| 7Q90 | Crystal structure of TTBK2 in complex with VNG1.63 (compound 32) | x-ray diffraction | A, B | PO4, 9IS | — |
| Q6IQ55 | AlphaFold monomer V2.0 prediction for tau-tubulin kinase 2 (Q6IQ55) | — | — | — |
Ligands
- PO4 · Phosphate ion · in 10 records
- 9IK · ~{N}-(4-phenoxyphenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- 9IS · ~{N}-[4-(4-methoxyphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- 9IV · ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- DTQ · 4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline · in 2 records
- MG · Magnesium ion · in 2 records
- NA · Sodium ion · in 2 records
Experiment against prediction
- 7O3B chain G against the predicted model Q9UPV0: TM-score 0.77, RMSD 2.03 Å
- 7O3B chain G against the predicted model Q9UPV0: TM-score 0.77, RMSD 2.03 Å
- 7O3B chain I against the predicted model Q9UPV0: TM-score 0.77, RMSD 2.06 Å
- 7O3B chain I against the predicted model Q9UPV0: TM-score 0.77, RMSD 2.06 Å
- 7O3B chain H against the predicted model Q9UPV0: TM-score 0.76, RMSD 2.08 Å
- 7O3B chain H against the predicted model Q9UPV0: TM-score 0.76, RMSD 2.08 Å
Elsewhere
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