Research workbench
Calmodulin extracts the RAS family protein rala from lipid bilayers by engagement with two membrane targeting motifs
Analyse Calmodulin extracts the RAS family protein rala from lipid bilayers by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NQC
- Type
- protein
- Length
- 166 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin-1; Pro-asn-gly-lys-lys-lys-arg-lys-ser-leu-ala-lys-arg-ile- arg-glu-arg-cmf
- EC
- 3.6.5.2
- UniProt
- P0DP29
- Ligands
- ULW, CA
- Pockets
- 1 · best druggability 0.53
Structure
solution nmr · 2 distinct chains · 49% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin-1 | protein | 148 | 55% helix, 3% strand | P0DP29 |
| B | Pro-asn-gly-lys-lys-lys-arg-lys-ser-leu-ala-lys-arg-ile- arg-glu-arg-cmf (EC 3.6.5.2) | protein | 18 | 0% helix, 0% strand | — |
Ligands and binding sites
- ULW · [(2~{Z},6~{Z})-3,7,11-trimethyldodeca-2,6-dienyl] 3-[2, 5-bis(oxidanylidene)pyrrolidin-1-yl]propanoate · ligand · chains A, B
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.53 | 0.78 | 26 | ULW |
Interfaces
1 interface between chains.
- A–B · 755 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 7NQC · Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with… · the same entry in another collection · chain A against A, TM-score 1.00
- P0DP29 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP29) · a predicted model of the same protein · chain A against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DP29
- Elsewhere: RCSB PDB 7NQC · PDBe 7NQC · UniProt P0DP29
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