Research workbench
Cryo-EM structure of human excitatory amino acid transporters-1 (EAAT1) in potassium buffer
Analyse Cryo-EM structure of human excitatory amino acid transporters-1 (EAAT1) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NPW
- Type
- protein
- Length
- 1,278 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Excitatory amino acid transporter 1
- UniProt
- P43003
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 73% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Excitatory amino acid transporter 1 | protein | 426 | 73% helix, 2% strand | P43003 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1077 | 0.85 | 0.85 | 70 | empty |
| 2 | 868 | 0.81 | 0.83 | 93 | empty |
| 3 | 874 | 0.81 | 0.83 | 107 | empty |
| 4 | 903 | 0.81 | 0.82 | 108 | empty |
| 5 | 282 | 0.69 | 0.83 | 37 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1262 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1259 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1238 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7NPW · Cryo-EM structure of Human excitatory amino acid transporters-1 (EAAT1) in potassium… · the same entry in another collection · chain A against A, TM-score 1.00
- P43003 · AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 1 (P43003) · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43003
- Elsewhere: RCSB PDB 7NPW · PDBe 7NPW · UniProt P43003
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.