Research workbench
OC43 coronavirus methyltransferase
Analyse OC43 coronavirus methyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NH7
- Type
- protein
- Length
- 415 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicase polyprotein 1AB; Replicase polyprotein 1A
- EC
- 3.4.19.12, 3.4.22.69, 3.4.22.-, 2.7.7.48, 3.6.4.12, 3.6.4.13, 2.1.1.-, 3.1.13.-, 3.1.-.-
- UniProt
- P0C6X6, P0C6U7
- Ligands
- SFG, ZN
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replicase polyprotein 1AB (EC 3.4.19.12, 3.4.22.69, 3.4.22.-, 2.7.7.48, 3.6.4.12, 3.6.4.13, 2.1.1.-, 3.1.13.-, 3.1.-.-) | protein | 295 | 27% helix, 20% strand | P0C6X6 |
| B | Replicase polyprotein 1A (EC 3.4.19.12, 3.4.22.69, 3.4.22.-) | protein | 120 | 28% helix, 13% strand | P0C6U7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.55 | 0.76 | 51 | SFG |
| 2 | 204 | 0.51 | 0.77 | 38 | empty |
| 3 | 141 | 0.45 | 0.76 | 22 | empty |
| 4 | 52 | 0.36 | 0.79 | 15 | empty |
| 5 | 57 | 0.33 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1046 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7NH7 · OC43 coronavirus methyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C6X6
- Every structure of UniProt P0C6U7
- Elsewhere: RCSB PDB 7NH7 · PDBe 7NH7 · UniProt P0C6X6 · UniProt P0C6U7
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