Crystal structure of the human HSP40 DNAJB1-ctds in complex with a peptide of nudc

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 40% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 649 Ų buried · 6 hydrogen bonds · protein-protein

Compared structures

• 7NDX · Crystal structure of the human HSP40 DNAJB1-CTDs in complex with a peptide of NudC · the same entry in another collection · chain A against A, TM-score 1.00
• P25685 · AlphaFold monomer V2.0 prediction for dnaj homolog subfamily B member 1 (P25685) · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q9Y266 · AlphaFold monomer V2.0 prediction for nuclear migration protein nudc (Q9Y266) · a predicted model of the same protein · chain B against A, TM-score 0.67

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P25685
• Every structure of UniProt Q9Y266
• Elsewhere: RCSB PDB 7NDX · PDBe 7NDX · UniProt P25685 · UniProt Q9Y266