UniProt P25685
DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha (P25685)
DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha (UniProt P25685), EC 2.7.11.11: 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 39 pockets. Binding sites…
- UniProt
- P25685
- Protein
- DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic…
- EC
- 2.7.11.11
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 39 · 3 records with a druggable one
Structures
23 records of P25685 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HDJ | Human HSP40 (hdj-1), NMR | solution nmr | A | — | — |
| 1HDJ | Human HSP40 (hdj-1), NMR | solution nmr | A | — | — |
| 2QLD | human Hsp40 Hdj1 | x-ray diffraction | A | — | — |
| 2QLD | Human HSP40 HDJ1 | x-ray diffraction | A | — | — |
| 3AGX | Crystal structure of human Hsp40 Hdj1 peptide-binding domain | x-ray diffraction | A, B | — | — |
| 3AGX | Crystal structure of human HSP40 HDJ1 peptide-binding domain | x-ray diffraction | A, B | — | — |
| 3AGY | Crystal structure of human Hsp40 Hdj1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | A, B | — | — |
| 3AGY | Crystal structure of human HSP40 HDJ1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | A, B | — | — |
| 3AGZ | Crystal structure of human Hsp40 Hdj1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | A, B | — | — |
| 3AGZ | Crystal structure of human HSP40 HDJ1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | A, B | — | — |
| 4WB7 | Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A… | x-ray diffraction | A, B | — | — |
| 4WB7 | Crystal structure of a chimeric fusion of human dnaj (HSP40) and camp- dependent protein kinase a… | x-ray diffraction | A, B | — | — |
| 6BYR | Structures of the PKA ri alpha holoenzyme with the flhcc driver J-pkac alpha or native pkac alpha | x-ray diffraction | A, C | ATP, MG | — |
| 6WJF | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | electron microscopy | A, B | — | — |
| 6WJF | PKA riibeta holoenzyme with DNAJB1-pkac fusion in fibrolamellar hepatoceullar carcinoma | electron microscopy | A, B | — | — |
| 6WJG | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | electron microscopy | A, B | — | 18 (best 0.86) |
| 6WJG | PKA riibeta holoenzyme with DNAJB1-pkac fusion in fibrolamellar hepatoceullar carcinoma | electron microscopy | A, B | — | — |
| 6Z5N | DnaJB1 JD-GF | solution nmr | A | — | — |
| 6Z5N | DNAJB1 jd-gf | solution nmr | A | — | — |
| 7NDX | Crystal structure of the human HSP40 DNAJB1-ctds in complex with a peptide of nudc | x-ray diffraction | A | — | — |
| 8FE5 | Structure of J-PKAc chimera complexed with Aplithianine B | x-ray diffraction | A, B | XTT | 12 (best 0.79) |
| 8FEC | Structure of J-PKAc chimera complexed with Aplithianine derivative | x-ray diffraction | A, B | XU0 | 9 (best 0.79) |
| P25685 | AlphaFold monomer V2.0 prediction for dnaj homolog subfamily B member 1 (P25685) | predicted | A | — | — |
Ligands
- ATP · Adenosine-5'-triphosphate · in 1 record
- MG · Magnesium ion · in 1 record
- XTT · 6-[(6P)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7,9-dihydro-8H-purin-8-one · in 1 record
- XU0 · 6-[(6P)-6-(4-bromo-1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-7H-purine · in 1 record
Experiment against prediction
- 8FE5 chain A against the predicted model P17612: TM-score 0.86, RMSD 0.93 Å
- 8FEC chain B against the predicted model P17612: TM-score 0.86, RMSD 1.04 Å
- 8FEC chain A against the predicted model P17612: TM-score 0.86, RMSD 1.07 Å
- 4WB7 chain A against the predicted model P17612: TM-score 0.85, RMSD 1.18 Å
- 4WB7 chain A against the predicted model P17612: TM-score 0.85, RMSD 1.18 Å
- 8FE5 chain B against the predicted model P17612: TM-score 0.85, RMSD 1.32 Å
- 6BYR chain A against the predicted model P17612: TM-score 0.85, RMSD 1.12 Å
- 3AGX chain B against the predicted model P25685: TM-score 0.97, RMSD 0.76 Å
- 3AGX chain B against the predicted model P25685: TM-score 0.97, RMSD 0.76 Å
- 7NDX chain A against the predicted model P25685: TM-score 0.97, RMSD 0.78 Å
Elsewhere
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