Research workbench
Type 1B alpha-synuclein filament seeded in vitro by filaments purified from multiple systems atrophy case 1
Analyse Type 1B alpha-synuclein filament seeded in vitro by filaments purified from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NCH
- Type
- protein
- Length
- 816 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 10 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 0% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Alpha-synuclein | protein | 68 | 0% helix, 41% strand | P37840 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.77 | 0.91 | 58 | empty |
| 2 | 259 | 0.76 | 0.90 | 59 | empty |
| 3 | 397 | 0.59 | 0.75 | 47 | empty |
| 4 | 319 | 0.58 | 0.77 | 40 | empty |
| 5 | 78 | 0.51 | 0.84 | 30 | empty |
Interfaces
30 interfaces between chains.
- K–L · 2653 Ų buried · 52 hydrogen bonds · protein-protein
- E–F · 2653 Ų buried · 51 hydrogen bonds · protein-protein
- C–D · 2636 Ų buried · 62 hydrogen bonds · protein-protein
- D–E · 2623 Ų buried · 61 hydrogen bonds · protein-protein
- B–C · 2622 Ų buried · 67 hydrogen bonds · protein-protein
Compared structures
- 7NCH · Type 1B alpha-synuclein filament seeded in vitro by filaments purified from Multiple… · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 7NCH · PDBe 7NCH · UniProt P37840
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.