Research workbench
Type 1A alpha-synuclein filament seeded in vitro by filaments purified from multiple systems atrophy case 2
Analyse Type 1A alpha-synuclein filament seeded in vitro by filaments purified from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NCA
- Type
- protein
- Length
- 732 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 5 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 0% helix, 61% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Alpha-synuclein | protein | 61 | 0% helix, 61% strand | P37840 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 859 | 0.82 | 0.84 | 83 | empty |
| 2 | 909 | 0.81 | 0.83 | 81 | empty |
| 3 | 79 | 0.65 | 0.91 | 26 | empty |
| 4 | 51 | 0.54 | 0.89 | 20 | empty |
| 5 | 200 | 0.44 | 0.73 | 28 | empty |
Interfaces
26 interfaces between chains.
- B–C · 2319 Ų buried · 45 hydrogen bonds · protein-protein
- A–E · 2317 Ų buried · 44 hydrogen bonds · protein-protein
- G–I · 2286 Ų buried · 36 hydrogen bonds · protein-protein
- J–L · 2275 Ų buried · 34 hydrogen bonds · protein-protein
- D–H · 2263 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7NCA · Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 7NCA · PDBe 7NCA · UniProt P37840
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