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Human importin alpha 1 in complex with BIMAX2 peptide

Analyse Human importin alpha 1 in complex with BIMAX2 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7N8J
Type: protein
Length: 447 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; BIMAX2
UniProt: P52292
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	422	74% helix, 0% strand	P52292
B	BIMAX2	protein	25	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.52	0.85	12	empty
2	69	0.44	0.81	15	empty

Interfaces

1 interface between chains.

A–B · 2027 Å² buried · 52 hydrogen bonds · protein-protein

Compared structures

7N8J · Human importin alpha 1 in complex with Bimax2 peptide · the same entry in another collection · chain A against A, TM-score 1.00
P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52292
Elsewhere: RCSB PDB 7N8J · PDBe 7N8J · UniProt P52292

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