Research workbench
Crystal structure of LIN9-RBAP48-LIN37, a muvb subcomplex
Analyse Crystal structure of LIN9-RBAP48-LIN37, a muvb subcomplex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7N40
- Type
- protein
- Length
- 587 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-binding protein RBBP4; Isoform 2 of protein lin-9 homolog; Protein lin-37 homolog
- UniProt
- Q09028, Q5TKA1, Q96GY3
- Pockets
- 11 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-binding protein RBBP4 | protein | 398 | 8% helix, 44% strand | Q09028 |
| B | Isoform 2 of protein lin-9 homolog | protein | 157 | 48% helix, 19% strand | Q5TKA1 |
| C | Protein lin-37 homolog | protein | 32 | 38% helix, 25% strand | Q96GY3 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.75 | 0.86 | 31 | empty |
| 2 | 323 | 0.66 | 0.81 | 36 | empty |
| 3 | 212 | 0.57 | 0.79 | 29 | empty |
| 4 | 106 | 0.52 | 0.82 | 18 | empty |
| 5 | 109 | 0.48 | 0.80 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2943 Ų buried · 47 hydrogen bonds · protein-protein
- B–C · 1118 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 457 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7N40 · Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex · the same entry in another collection · chain A against A, TM-score 1.00
- Q09028 · AlphaFold monomer V2.0 prediction for histone-binding protein RBBP4 (Q09028) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q5TKA1 · AlphaFold monomer V2.0 prediction for protein lin-9 homolog (Q5TKA1) · a predicted model of the same protein · chain B against A, TM-score 0.90
- Q96GY3 · AlphaFold monomer V2.0 prediction for protein lin-37 homolog (Q96GY3) · a predicted model of the same protein · chain C against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09028
- Every structure of UniProt Q5TKA1
- Every structure of UniProt Q96GY3
- Elsewhere: RCSB PDB 7N40 · PDBe 7N40 · UniProt Q09028 · UniProt Q5TKA1 · UniProt Q96GY3
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