Research workbench
Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder
Analyse Crystal structure of FGFR4 domain 3 in complex with a de novo-designed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7N1J
- Type
- protein
- Length
- 355 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 4; Binder
- EC
- 2.7.10.1
- UniProt
- P22455
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 32% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 4 (EC 2.7.10.1) | protein | 125 | 2% helix, 44% strand | P22455 |
| B | Binder | protein | 64 | 81% helix, 0% strand | — |
| C | Fibroblast growth factor receptor 4 (EC 2.7.10.1) | protein | 103 | 3% helix, 52% strand | P22455 |
| D | Binder | protein | 63 | 86% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.62 | 0.87 | 33 | empty |
Interfaces
6 interfaces between chains.
- A–B · 864 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 852 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 390 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 201 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 189 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7N1J · Crystal structure of FGFR4 domain 3 in complex with a de novo-designed mini-binder · the same entry in another collection · chain A against A, TM-score 1.00
- P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain C against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22455
- Elsewhere: RCSB PDB 7N1J · PDBe 7N1J · UniProt P22455
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