Research workbench

Cryo-EM structure of tacan in the apo form (TMEM120A)

Analyse Cryo-EM structure of tacan in the apo form (TMEM120A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7N0K
Type: protein
Length: 626 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ion channel tacan
UniProt: Q8C1E7
Pockets: 6 · best druggability 0.76

Structure

electron microscopy · 1 distinct chain · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Ion channel tacan	protein	313	83% helix, 0% strand	Q8C1E7

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	761	0.76	0.81	59	empty
2	752	0.76	0.81	64	empty
3	539	0.67	0.77	56	empty
4	406	0.62	0.77	46	empty
5	84	0.36	0.76	19	empty

Interfaces

1 interface between chains.

B–A · 3288 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

7N0K · Cryo-EM structure of TACAN in the apo form (TMEM120A) · the same entry in another collection · chain A against A, TM-score 1.00
Q8C1E7 · AlphaFold monomer V2.0 prediction for ion channel tacan (Q8C1E7) · a predicted model of the same protein · chain B against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8C1E7
Elsewhere: RCSB PDB 7N0K · PDBe 7N0K · UniProt Q8C1E7

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