Research workbench
HUWE1 in MAP with focus on interface
Analyse HUWE1 in MAP with focus on interface in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MWF
- Type
- protein
- Length
- 2,427 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase HUWE1
- EC
- 2.3.2.26
- UniProt
- Q7Z6Z7
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 65% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) | protein | 2427 | 65% helix, 5% strand | Q7Z6Z7 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 953 | 0.76 | 0.79 | 89 | empty |
| 2 | 715 | 0.74 | 0.80 | 81 | empty |
| 3 | 538 | 0.69 | 0.79 | 49 | empty |
| 4 | 348 | 0.64 | 0.79 | 47 | empty |
| 5 | 310 | 0.57 | 0.77 | 31 | empty |
Compared structures
- 7MWF · HUWE1 in map with focus on interface · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z6Z7
- Elsewhere: RCSB PDB 7MWF · PDBe 7MWF · UniProt Q7Z6Z7
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