Research workbench
Mouse CNTN5 app complex
Analyse Mouse CNTN5 app complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MRN
- Type
- protein
- Length
- 810 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Contactin-5; N-app
- UniProt
- P68500, P12023
- Pockets
- 9 · best druggability 0.53
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Contactin-5 | protein | 285 | 1% helix, 43% strand | P68500 |
| C | N-app | protein | 131 | 16% helix, 39% strand | P12023 |
| B | Contactin-5 | protein | 267 | 1% helix, 45% strand | P68500 |
| D | N-app | protein | 127 | 17% helix, 38% strand | P12023 |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 275 | 0.53 | 0.75 | 44 | empty |
| 2 | 208 | 0.47 | 0.74 | 33 | empty |
| 3 | 94 | 0.38 | 0.75 | 18 | empty |
| 4 | 59 | 0.35 | 0.78 | 19 | empty |
| 5 | 65 | 0.31 | 0.75 | 16 | empty |
Interfaces
4 interfaces between chains.
- A–C · 650 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 578 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 402 Ų buried · 9 hydrogen bonds · protein-protein
- C–B · 319 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 7MRN · Mouse CNTN5 APP complex · the same entry in another collection · chain B against B, TM-score 1.00
- P12023 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 protein (P12023) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P68500 · AlphaFold monomer V2.0 prediction for contactin-5 (P68500) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68500
- Every structure of UniProt P12023
- Elsewhere: RCSB PDB 7MRN · PDBe 7MRN · UniProt P68500 · UniProt P12023
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