Research workbench
The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Analyse The insulin receptor ectodomain in complex with three venom hybrid insulin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MQS
- Type
- protein
- Length
- 1,739 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform short of insulin receptor; Insulin a chain; Insulin B chain
- EC
- 2.7.10.1
- UniProt
- P01308
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 9% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 806 | 8% helix, 31% strand | — |
| F | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 811 | 8% helix, 29% strand | — |
| A, C, G | Insulin a chain | protein | 24 | 46% helix, 0% strand | P01308 |
| B, D | Insulin B chain | protein | 16 | 56% helix, 0% strand | P01308 |
| H | Insulin B chain | protein | 18 | 50% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.85 | 0.94 | 51 | empty |
| 2 | 790 | 0.81 | 0.84 | 73 | empty |
| 3 | 870 | 0.79 | 0.82 | 85 | empty |
| 4 | 77 | 0.73 | 0.96 | 25 | empty |
| 5 | 130 | 0.71 | 0.91 | 31 | empty |
Interfaces
14 interfaces between chains.
- E–F · 2722 Ų buried · 29 hydrogen bonds · protein-protein
- F–A · 677 Ų buried · 9 hydrogen bonds · protein-protein
- G–H · 542 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 475 Ų buried · 2 hydrogen bonds · protein-protein
- E–G · 441 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 44 disulfide (disulfide).
Compared structures
- 7MQS · The insulin receptor ectodomain in complex with three venom hybrid insulin molecules… · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7MQS · PDBe 7MQS · UniProt P01308
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