Research workbench
Neurofibromin homodimer
Analyse Neurofibromin homodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MP6
- Type
- protein
- Length
- 3,209 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform I of neurofibromin
- UniProt
- P21359
- Pockets
- 20 · best druggability 0.67
Structure
electron microscopy · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform I of neurofibromin | protein | 1600 | 79% helix, 0% strand | P21359 |
| B | Isoform I of neurofibromin | protein | 1609 | 78% helix, 0% strand | P21359 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.67 | 0.90 | 19 | empty |
| 2 | 106 | 0.65 | 0.89 | 21 | empty |
| 3 | 264 | 0.56 | 0.77 | 33 | empty |
| 4 | 280 | 0.56 | 0.77 | 57 | empty |
| 5 | 194 | 0.54 | 0.79 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 4750 Ų buried · 44 hydrogen bonds · protein-protein
Compared structures
- 7MP6 · Neurofibromin homodimer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21359
- Elsewhere: RCSB PDB 7MP6 · PDBe 7MP6 · UniProt P21359
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