Research workbench
Cryo-EM structure of 2:2 C-MET/NK1 complex
Analyse Cryo-EM structure of 2:2 C-MET/NK1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MOB
- Type
- protein
- Length
- 1,322 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor; Hepatocyte growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P14210, P08581
- Pockets
- 20 · best druggability 0.68
Structure
electron microscopy · 2 distinct chains · 7% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Hepatocyte growth factor | protein | 172 | 7% helix, 26% strand | P14210 |
| C, D | Hepatocyte growth factor receptor (EC 2.7.10.1) | protein | 489 | 7% helix, 40% strand | P08581 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 620 | 0.68 | 0.77 | 56 | empty |
| 2 | 613 | 0.67 | 0.77 | 52 | empty |
| 3 | 50 | 0.65 | 0.95 | 17 | empty |
| 4 | 365 | 0.63 | 0.78 | 64 | empty |
| 5 | 253 | 0.61 | 0.80 | 32 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1054 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 951 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 945 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 28 disulfide (disulfide).
Compared structures
- 7MOB · Cryo-EM structure of 2:2 c-MET/NK1 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14210
- Every structure of UniProt P08581
- Elsewhere: RCSB PDB 7MOB · PDBe 7MOB · UniProt P14210 · UniProt P08581
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