Research workbench
Glutamate synthase, glutamate dehydrogenase counter-enzyme complex (GUDB6-GLTA6-GLTB6)
Analyse Glutamate synthase, glutamate dehydrogenase counter-enzyme complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MFT
- Type
- protein
- Length
- 2,383 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate dehydrogenase; Glutamate synthase (NADPH) large chain; Glutamate synthase…
- UniProt
- A0A0C3GZC9, A0A164XVV7, A0A164XVU4
- Ligands
- SF4, FMN, F3S, FAD
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 3 distinct chains · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate dehydrogenase | protein | 410 | 48% helix, 12% strand | A0A0C3GZC9 |
| G | Glutamate synthase (NADPH) large chain | protein | 1483 | 38% helix, 15% strand | A0A164XVV7 |
| I | Glutamate synthase (NADPH) small chain | protein | 490 | 34% helix, 11% strand | A0A164XVU4 |
Ligands and binding sites
- SF4 · Iron/sulfur cluster · ligand · 2 copies · chains I
- FMN · Flavin mononucleotide · ligand · chains G
- F3S · FE3-S4 cluster · ligand · chains G
- FAD · Flavin-adenine dinucleotide · ligand · chains I
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1072 | 0.87 | 0.89 | 130 | FMN, F3S |
| 2 | 943 | 0.86 | 0.88 | 95 | empty |
| 3 | 954 | 0.82 | 0.84 | 106 | FAD |
| 4 | 1139 | 0.82 | 0.83 | 99 | empty |
| 5 | 67 | 0.73 | 0.98 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–G · 2144 Ų buried · 16 hydrogen bonds · protein-protein
- G–I · 1950 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 7MFT · Glutamate synthase, glutamate dehydrogenase counter-enzyme complex (GudB6-GltA6-GltB6) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0C3GZC9
- Every structure of UniProt A0A164XVV7
- Every structure of UniProt A0A164XVU4
- Elsewhere: RCSB PDB 7MFT · PDBe 7MFT · UniProt A0A0C3GZC9 · UniProt A0A164XVV7 · UniProt A0A164XVU4
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