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Crystal structure of UP1 complexed with D(TTAGGGTTAG(6-mi) G); a human telomeric repeat containing 6-methyl-8-(2- deoxy-beta-RIBOFURANOSYL)ISOXANTHOPTERIDINE (6-mi)

Analyse Crystal structure of UP1 complexed with D(TTAGGGTTAG(6-mi) G); a human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PGZ
Type: protein + DNA
Length: 193 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*T*TP*AP*GP*GP*GP*TP*TP*AP*GP*(6MI)P*G)-3'; Heterogeneous nuclear ribonucleoprotein…
UniProt: P09651
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	5'-D(TTPAPGPGPGPTPTPAPGP(6MI)PG)-3'	dna	10	—	—
A	Heterogeneous nuclear ribonucleoprotein A1	protein	183	29% helix, 33% strand	P09651

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	192	0.55	0.79	27	empty

Interfaces

1 interface between chains.

B–A · 804 Å² buried · 22 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 modified (nucleotide modification).

Compared structures

1PGZ · Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat… · the same entry in another collection · chain B against B, TM-score 1.00
P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain A against A, TM-score 0.98

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09651
Elsewhere: RCSB PDB 1PGZ · PDBe 1PGZ · UniProt P09651

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