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NMR solution structure of an oxaliplatin 1,2-D(GG) intrastrand cross- link in a DNA dodecamer duplex

Analyse NMR solution structure of an oxaliplatin 1,2-D(GG) intrastrand cross- link in a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PG9
Type: DNA
Length: 24 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3'; 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3'
Ligands: 1PT

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-D(CPCPTPCPAPGPGPCPCPTPCPC)-3'	dna	12	—	—
B	5'-D(GPGPAPGPGPCPCPTPGPAPGPG)-3'	dna	12	—	—

Ligands and binding sites

1PT · Cyclohexane-1(R),2(R)-diamine-platinum(ii) · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 572 Å² buried · 58 hydrogen bonds · nucleic-nucleic

Compared structures

1PG9 · NMR Solution Structure of an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link in a DNA… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1PG9 · PDBe 1PG9

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