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Ligand · 1PT

1PT · Cyclohexane-1(R),2(R)-diamine-platinum(ii)

1PT, Cyclohexane-1(R),2(R)-diamine-platinum(ii) (C6 H14 N2 Pt +2, 309.3 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and…

Component
1PT
Formula
C6 H14 N2 Pt +2
Class
ligand
Structures
16
PDB entries
8

Binding sites

1PT in 16 structures; the first of them:

  • 1PG9 · NMR Solution Structure of an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link in a DNA… · 1PT A77 · binds DA5, DG6, DG7, DC8
  • 1PGC · NMR Solution Structure of an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link in a DNA… · 1PT A77 · binds DA5, DG6, DG7
  • 2K0T · High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct · 1PT A13 · binds DT5, DG6, DG7, DT8, DA17
  • 2K0U · High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct · 1PT A13 · binds DT5, DG6, DG7, DT8, DA17
  • 4PPO · First Crystal Structure for an Oxaliplatin-Protein Complex · 1PT A210 · binds ASP119, GLN121
  • 4S18 · The X-ray structure of the adduct formed in the reaction between bovine pancreatic… · 1PT A201 · binds ALA4, LYS7, VAL118, HIS119
  • 4Z46 · X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the… · 1PT A214 · binds ASP119, GLN121
  • 4ZEE · X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the… · 1PT A412 · binds ASP119, GLN121, ARG125
  • 1PG9 · NMR solution structure of an oxaliplatin 1,2-D(GG) intrastrand cross- link in a DNA… · 1PT A77 · binds DA5, DG6, DG7, DC8
  • 1PGC · NMR solution structure of an oxaliplatin 1,2-D(GG) intrastrand cross- link in a DNA… · 1PT A77 · binds DA5, DG6, DG7
  • 2K0T · High resolution solution NMR structures of oxaliplatin-DNA adduct · 1PT A13 · binds DT5, DG6, DG7, DT8, DA17
  • 2K0U · High resolution solution NMR structures of oxaliplatin-DNA adduct · 1PT A13 · binds DT5, DG6, DG7, DT8, DA17
  • 4PPO · First crystal structure for an oxaliplatin-protein complex · 1PT A210 · binds ASP119, GLN121
  • 4S18 · The X-ray structure of the adduct formed in the reaction between bovine pancreatic… · 1PT A201 · binds ALA4, LYS7, VAL118, HIS119
  • 4Z46 · X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the… · 1PT A214 · binds ASP119, GLN121
  • 4ZEE · X-ray structure of the bis-platinum lysozyme adduct formed in the reaction between the… · 1PT A412 · binds ASP119, GLN121, ARG125

Residues it binds most

DG 8, ASP 10, DA 8, DT 4, GLN 8, HIS 8, LYS 4, MET 4, SER 2, THR 4 (residue and the binding sites it lines).

Found with

  • NO3 · Nitrate ion
  • EDO · 1,2-ethanediol
  • CPT · Cisplatin
  • NA · Sodium ion

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