Research workbench
Human neurofibromin 2/MERLIN residues 1-339 in complex with LATS1
Analyse Human neurofibromin 2/MERLIN residues 1-339 in complex with LATS1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LWH
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Merlin; SERINE/THREONINE-protein kinase LATS1
- EC
- 2.7.11.1
- UniProt
- P35240, O95835
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Merlin | protein | 315 | 40% helix, 21% strand | P35240 |
| B | SERINE/THREONINE-protein kinase LATS1 (EC 2.7.11.1) | protein | 23 | 74% helix, 4% strand | O95835 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.64 | 0.77 | 46 | empty |
| 2 | 124 | 0.54 | 0.82 | 17 | empty |
| 3 | 89 | 0.47 | 0.81 | 24 | IMD |
| 4 | 54 | 0.44 | 0.83 | 21 | empty |
| 5 | 150 | 0.41 | 0.74 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 870 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7LWH · Human neurofibromin 2/merlin residues 1-339 in complex with LATS1 · the same entry in another collection · chain A against A, TM-score 1.00
- P35240 · AlphaFold monomer V2.0 prediction for merlin (P35240) · a predicted model of the same protein · chain A against A, TM-score 0.95
- O95835 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase LATS1 (O95835) · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35240
- Every structure of UniProt O95835
- Elsewhere: RCSB PDB 7LWH · PDBe 7LWH · UniProt P35240 · UniProt O95835
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