Research workbench
Prefusion rsv F glycoprotein bound by neutralizing site V-directed antibody adi-14442
Analyse Prefusion rsv F glycoprotein bound by neutralizing site V-directed antibody… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LUE
- Type
- protein
- Length
- 1,947 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0; Heavy chain of human antibody Fab adi-14442; Light chain of human…
- UniProt
- W8RJF9
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 21% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Fusion glycoprotein F0 | protein | 427 | 30% helix, 35% strand | W8RJF9 |
| H, I, J | Heavy chain of human antibody Fab adi-14442 | protein | 111 | 5% helix, 50% strand | — |
| L, M, N | Light chain of human antibody Fab adi-14442 | protein | 111 | 3% helix, 51% strand | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1159 | 0.85 | 0.86 | 96 | empty |
| 2 | 629 | 0.77 | 0.82 | 109 | empty |
| 3 | 856 | 0.71 | 0.76 | 64 | empty |
| 4 | 787 | 0.70 | 0.76 | 52 | empty |
| 5 | 767 | 0.70 | 0.76 | 55 | empty |
Interfaces
15 interfaces between chains.
- B–C · 1793 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1784 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 1784 Ų buried · 14 hydrogen bonds · protein-protein
- J–N · 754 Ų buried · 7 hydrogen bonds · protein-protein
- H–L · 750 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 27 disulfide (disulfide).
Compared structures
- 7LUE · Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt W8RJF9
- Elsewhere: RCSB PDB 7LUE · PDBe 7LUE · UniProt W8RJF9
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