Research workbench
Cama adenine methyltransferase complexed to cognate substrate DNA
Analyse Cama adenine methyltransferase complexed to cognate substrate DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LNJ
- Type
- protein + DNA
- Length
- 1,715 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Site-specific DNA-methyltransferase (adenine-specific); DNA strand 2; DNA strand 1
- EC
- 2.1.1.72
- UniProt
- Q183J3
- Pockets
- 20 · best druggability 0.68
Structure
x-ray diffraction · 6 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) | protein | 543 | 41% helix, 20% strand | Q183J3 |
| B | Site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) | protein | 550 | 40% helix, 20% strand | Q183J3 |
| C | Site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) | protein | 539 | 41% helix, 19% strand | Q183J3 |
| E | DNA strand 2 | dna | 13 | — | — |
| D, F, H | DNA strand 1 | dna | 14 | — | — |
| G, I | DNA strand 2 | dna | 14 | — | — |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 932 | 0.68 | 0.74 | 70 | empty |
| 2 | 440 | 0.67 | 0.80 | 44 | empty |
| 3 | 378 | 0.66 | 0.80 | 43 | empty |
| 4 | 365 | 0.64 | 0.79 | 41 | empty |
| 5 | 330 | 0.62 | 0.79 | 34 | empty |
Interfaces
18 interfaces between chains.
- C–H · 1322 Ų buried · 30 hydrogen bonds · protein-nucleic
- B–F · 1311 Ų buried · 28 hydrogen bonds · protein-nucleic
- A–D · 1299 Ų buried · 25 hydrogen bonds · protein-nucleic
- B–G · 1128 Ų buried · 20 hydrogen bonds · protein-nucleic
- A–E · 1110 Ų buried · 20 hydrogen bonds · protein-nucleic
Compared structures
- 7LNJ · CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q183J3
- Elsewhere: RCSB PDB 7LNJ · PDBe 7LNJ · UniProt Q183J3
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