UniProt Q183J3
Site-specific DNA-methyltransferase (adenine-specific) (Q183J3)
Site-specific DNA-methyltransferase (adenine-specific) (UniProt Q183J3), EC 2.1.1.72: 14 experimental structures on GenesisL1, 8 ligands bound, 100 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q183J3
- Protein
- Site-specific DNA-methyltransferase (adenine-specific)
- EC
- 2.1.1.72
- Experimental structures
- 14
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 100 · 5 records with a druggable one
Structures
14 records of Q183J3 in the MolNFT archive: 14 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7LNI | Semet cama adenine methyltransferase complexed to cognate substrate DNA | x-ray diffraction | A, B, C | — | — |
| 7LNJ | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA | x-ray diffraction | A, B, C | — | — |
| 7LNJ | Cama adenine methyltransferase complexed to cognate substrate DNA | x-ray diffraction | A, B, C | — | — |
| 7LT5 | Cama adenine methyltransferase complexed to cognate substrate DNA and cofactor sah | x-ray diffraction | A, B, C | — | — |
| 7RFK | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor Sinefungin | x-ray diffraction | A, B, C | SFG, K | 20 (best 0.72) |
| 7RFK | Cama adenine methyltransferase complexed to cognate substrate DNA and inhibitor sinefungin | x-ray diffraction | A, B, C | K | — |
| 7RFL | Cama adenine methyltransferase complexed to cognate substrate DNA and inhibitor SGC0946 | x-ray diffraction | A, B, C | AW2, K | — |
| 7RFM | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor EPZ004777 | x-ray diffraction | A, B, C | 0QK, K | 20 (best 0.69) |
| 7RFM | Cama adenine methyltransferase complexed to cognate substrate DNA and inhibitor EPZ004777 | x-ray diffraction | A, B, C | 0QK, K | — |
| 7RFN | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor SGC8158 | x-ray diffraction | A, B, C | MJ7, K | 20 (best 0.69) |
| 7RFN | Cama adenine methyltransferase complexed to cognate substrate DNA and inhibitor SGC8158 | x-ray diffraction | A, B, C | MJ7, K | — |
| 8CXT | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-benzyladenosine… | x-ray diffraction | A, B, C | K, Q8C | — |
| 8CXV | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 3 | x-ray diffraction | A, B, C | K, T9R | 20 (best 0.69) |
| 8CXX | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 6 | x-ray diffraction | A, B, C | K, T9I | 20 (best 0.69) |
Ligands
- K · Potassium ion · in 10 records
- 0QK · 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl) (propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 2 records
- MJ7 · 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl) methyl]amino}butyl)-5'-thioadenosine · in 2 records
- AW2 · 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl) carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
- Q8C · N-benzyladenosine · in 1 record
- SFG · Sinefungin · in 1 record
- T9I · N-[(1R)-2,3-dihydro-1H-inden-1-yl]adenosine · in 1 record
- T9R · N-[(4-hydroxyphenyl)methyl]adenosine · in 1 record
Elsewhere
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