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Infectious mammalian prion fibril (263K scrapie)

Analyse Infectious mammalian prion fibril (263K scrapie) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7LNA
Type: protein
Length: 390 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Major prion protein
UniProt: P04273
Pockets: 4 · best druggability 0.48

Structure

electron microscopy · 1 distinct chain · 0% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Major prion protein	protein	130	0% helix, 44% strand	P04273

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.48	0.82	17	empty
2	191	0.47	0.75	24	empty
3	216	0.46	0.74	28	empty
4	53	0.42	0.83	21	empty

Interfaces

3 interfaces between chains.

A–C · 6016 Å² buried · 165 hydrogen bonds · protein-protein
A–B · 6013 Å² buried · 165 hydrogen bonds · protein-protein
B–C · 286 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

7LNA · Infectious mammalian prion fibril (263K scrapie) · the same entry in another collection · chain A against A, TM-score 1.00
P04273 · AlphaFold monomer V2.0 prediction for major prion protein (P04273) · a predicted model of the same protein · chain A against A, TM-score 0.20

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04273
Elsewhere: RCSB PDB 7LNA · PDBe 7LNA · UniProt P04273

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