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Human U1A protein with F37M and F77M mutations for improved phasing

Analyse Human U1A protein with F37M and F77M mutations for improved phasing in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7LHX
Type: protein
Length: 96 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: U1 small nuclear ribonucleoprotein a
UniProt: P09012
Ligands: NA
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	U1 small nuclear ribonucleoprotein a	protein	96	32% helix, 25% strand	P09012

Ligands and binding sites

NA · Sodium ion · metal · chains A
ACT · Acetate ion · additive · 2 copies · chains A
BME · Beta-mercaptoethanol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.33	0.78	15	ACT

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

7LHX · Human U1A protein with F37M and F77M mutations for improved phasing · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09012
Elsewhere: RCSB PDB 7LHX · PDBe 7LHX · UniProt P09012

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