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Crystal structure of the MEILB2-BRCA2 complex

Analyse Crystal structure of the MEILB2-BRCA2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7LDG
Type: protein
Length: 490 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock factor 2-binding protein; Breast cancer type 2 susceptibility protein
UniProt: O75031, P51587
Pockets: 6 · best druggability 0.61

Structure

x-ray diffraction · 4 distinct chains · 68% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock factor 2-binding protein	protein	220	78% helix, 0% strand	O75031
B	Breast cancer type 2 susceptibility protein	protein	50	8% helix, 10% strand	P51587
C	Heat shock factor 2-binding protein	protein	213	75% helix, 0% strand	O75031
D	Breast cancer type 2 susceptibility protein	protein	7	0% helix, 29% strand	P51587

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	261	0.61	0.80	35	empty
2	167	0.53	0.79	19	empty
3	68	0.48	0.84	13	empty
4	92	0.45	0.80	18	empty
5	103	0.41	0.77	23	empty

Interfaces

5 interfaces between chains.

A–C · 1575 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 1012 Å² buried · 20 hydrogen bonds · protein-protein
B–D · 310 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 224 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 23 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 11 modified, 1 disulfide (engineered, disulfide).

Compared structures

7LDG · Crystal structure of the MEILB2-BRCA2 complex · the same entry in another collection · chain A against A, TM-score 1.00
O75031 · AlphaFold monomer V2.0 prediction for heat shock factor 2-binding protein (O75031) · a predicted model of the same protein · chain C against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75031
Every structure of UniProt P51587
Elsewhere: RCSB PDB 7LDG · PDBe 7LDG · UniProt O75031 · UniProt P51587

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