Research workbench
Clobetasol propionate bound to CYP3A5
Analyse Clobetasol propionate bound to CYP3A5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LAD
- Type
- protein
- Length
- 447 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450 3A5
- EC
- 1.14.14.1
- UniProt
- P20815
- Ligands
- HEM, XRD
- Pockets
- 6 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 3A5 (EC 1.14.14.1) | protein | 447 | 53% helix, 10% strand | P20815 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- XRD · Clobetasol propionate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 856 | 0.88 | 0.90 | 88 | HEM, XRD |
| 2 | 151 | 0.49 | 0.78 | 22 | empty |
| 3 | 182 | 0.47 | 0.75 | 32 | empty |
| 4 | 143 | 0.44 | 0.75 | 24 | empty |
| 5 | 62 | 0.39 | 0.79 | 12 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20815
- Elsewhere: RCSB PDB 7LAD · PDBe 7LAD · UniProt P20815
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