Research workbench

Human mitochondrial chaperonin MHSP60

Analyse Human mitochondrial chaperonin MHSP60 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7L7S
Type: protein
Length: 3,668 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 60 kda heat shock protein, mitochondrial
EC: 5.6.1.7
UniProt: P10809
Pockets: 20 · best druggability 0.78

Structure

electron microscopy · 1 distinct chain · 47% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H, I, J, K, L, M, N	60 kda heat shock protein, mitochondrial (EC 5.6.1.7)	protein	524	47% helix, 11% strand	P10809

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	134	0.78	0.96	39	empty
2	844	0.78	0.81	119	empty
3	131	0.78	0.96	40	empty
4	129	0.77	0.95	38	empty
5	130	0.77	0.95	40	empty

Interfaces

7 interfaces between chains.

I–J · 1347 Å² buried · 14 hydrogen bonds · protein-protein
H–N · 1346 Å² buried · 15 hydrogen bonds · protein-protein
K–L · 1343 Å² buried · 14 hydrogen bonds · protein-protein
H–I · 1342 Å² buried · 14 hydrogen bonds · protein-protein
J–K · 1341 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7L7S · Human mitochondrial chaperonin mHsp60 · the same entry in another collection · chain N against N, TM-score 1.00
P10809 · AlphaFold monomer V2.0 prediction for 60 kda heat shock protein, mitochondrial (P10809) · a predicted model of the same protein · chain K against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10809
Elsewhere: RCSB PDB 7L7S · PDBe 7L7S · UniProt P10809

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