UniProt P10809
60 kDa heat shock protein, mitochondrial (P10809)
60 kDa heat shock protein, mitochondrial (UniProt P10809), EC 3.6.4.9, 5.6.1.7: 17 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 180 pockets. Binding sites, druggability and experiment against…
- UniProt
- P10809
- Protein
- 60 kDa heat shock protein, mitochondrial
- EC
- 3.6.4.9, 5.6.1.7
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 180 · 9 records with a druggable one
Structures
18 records of P10809 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4PJ1 | Crystal structure of the human mitochondrial chaperonin symmetrical 'football' complex | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N | — | — |
| 4PJ1 | Crystal structure of the human mitochondrial chaperonin symmetrical 'football' complex | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N | — | — |
| 6HT7 | Crystal structure of the WT human mitochondrial chaperonin (ADP:BeF3)14 complex | x-ray diffraction | J, I, H, N, M, L, K, G, F, E, D, C, B, A | ADP, BEF, MG, K | — |
| 6MRC | ADP-bound human mitochondrial Hsp60-Hsp10 football complex | electron microscopy | H, N, M, L, K, J, I, D, C, B, A, G, F, E | ADP, MG | 20 (best 0.83) |
| 6MRC | ADP-bound human mitochondrial HSP60-HSP10 football complex | electron microscopy | H, N, M, L, K, J, I, D, C, B, A, G, F, E | ADP, MG | — |
| 6MRD | ADP-bound human mitochondrial Hsp60-Hsp10 half-football complex | electron microscopy | A, G, F, E, D, C, B | ADP, MG | — |
| 6MRD | ADP-bound human mitochondrial HSP60-HSP10 half-football complex | electron microscopy | A, G, F, E, D, C, B | ADP, MG | — |
| 7AZP | Structure of the human mitochondrial HSPD1 single ring | electron microscopy | A, B, C, D, E, F, G | — | — |
| 7L7S | Human mitochondrial chaperonin mHsp60 | electron microscopy | H, I, J, K, L, M, N | — | 20 (best 0.78) |
| 7L7S | Human mitochondrial chaperonin MHSP60 | electron microscopy | H, I, J, K, L, M, N | — | — |
| 8G7J | mtHsp60 V72I apo | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.74) |
| 8G7K | mtHsp60 V72I apo focus | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.76) |
| 8G7L | ATP-bound mtHsp60 V72I | electron microscopy | A, G, F, E, D, C, B, K, J, I, H, N, M, L | ATP, MG, K | 20 (best 0.83) |
| 8G7M | ATP-bound mtHsp60 V72I focus | electron microscopy | A, B, C, D, E, F, G | ATP, MG, K | 20 (best 0.82) |
| 8G7N | ATP- and mtHsp10-bound mtHsp60 V72I | electron microscopy | A, G, F, E, D, C, B, J, I, H, N, Y, L, K | ATP, MG, K | 20 (best 0.82) |
| 8G7O | ATP- and mtHsp10-bound mtHsp60 V72I focus | electron microscopy | A, B, C, D, E, F, G | ATP | 20 (best 0.82) |
| 8U39 | Structure of Human Mitochondrial Chaperonin V72I mutant | electron microscopy | G, A, B, C, D, E, F | — | 20 (best 0.80) |
| P10809 | AlphaFold monomer V2.0 prediction for 60 kda heat shock protein, mitochondrial (P10809) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8G7M chain G against the predicted model P10809: TM-score 0.99, RMSD 0.63 Å
- 4PJ1 chain C against the predicted model P10809: TM-score 0.99, RMSD 0.65 Å
- 4PJ1 chain C against the predicted model P10809: TM-score 0.99, RMSD 0.65 Å
- 4PJ1 chain D against the predicted model P10809: TM-score 0.99, RMSD 0.69 Å
- 4PJ1 chain D against the predicted model P10809: TM-score 0.99, RMSD 0.69 Å
- 6HT7 chain I against the predicted model P10809: TM-score 0.98, RMSD 1.04 Å
- 4PJ1 chain I against the predicted model P10809: TM-score 0.98, RMSD 0.91 Å
- 4PJ1 chain I against the predicted model P10809: TM-score 0.98, RMSD 0.91 Å
- 4PJ1 chain F against the predicted model P10809: TM-score 0.98, RMSD 0.96 Å
- 4PJ1 chain F against the predicted model P10809: TM-score 0.98, RMSD 0.96 Å
Elsewhere
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