Research workbench
Structure of TRAF5 and TRAF6 ring hetero dimer
Analyse Structure of TRAF5 and TRAF6 ring hetero dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7L3L
- Type
- protein
- Length
- 482 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor-associated factor 5; TNF receptor-associated factor 6
- EC
- 2.3.2.27
- UniProt
- O00463, Q9Y4K3
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor-associated factor 5 | protein | 141 | 28% helix, 13% strand | O00463 |
| B | TNF receptor-associated factor 6 (EC 2.3.2.27) | protein | 107 | 31% helix, 19% strand | Q9Y4K3 |
| C | TNF receptor-associated factor 5 | protein | 136 | 27% helix, 15% strand | O00463 |
| D | TNF receptor-associated factor 6 (EC 2.3.2.27) | protein | 98 | 32% helix, 12% strand | Q9Y4K3 |
Ligands and binding sites
- ZN · Zinc ion · metal · 14 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.46 | 0.74 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 681 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 661 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 513 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7L3L · Structure of TRAF5 and TRAF6 RING Hetero dimer · the same entry in another collection · chain D against D, TM-score 1.00
- Q9Y4K3 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 6 (Q9Y4K3) · a predicted model of the same protein · chain D against A, TM-score 0.98
- O00463 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 5 (O00463) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00463
- Every structure of UniProt Q9Y4K3
- Elsewhere: RCSB PDB 7L3L · PDBe 7L3L · UniProt O00463 · UniProt Q9Y4K3
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