Human methionine adenosyltransferase 2A bound to methylthioadenosine and inhibitor, di-imido triphosphate (pnpnp)

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).

Ligands and binding sites

• XE1 · N,N'-(dihydroxy-lambda~5~-phosphanediyl) bis(phosphoramidic acid) · ligand · chains A
• MTA · 5'-deoxy-5'-methylthioadenosine · ligand · chains A
• ALA · Alanine · ligand · chains A
• NA · Sodium ion · metal · 6 copies · chains A
• MG · Magnesium ion · metal · 2 copies · chains A
• K · Potassium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7L1A · Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
• P31153 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-2… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P31153
• Elsewhere: RCSB PDB 7L1A · PDBe 7L1A · UniProt P31153