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Crystal structure of sugar-bound melibiose permease melb

Analyse Crystal structure of sugar-bound melibiose permease melb in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7L16
Type: protein
Length: 453 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Melibiose carrier protein
UniProt: P30878
Ligands: LMO
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Melibiose carrier protein	protein	453	81% helix, 0% strand	P30878

Ligands and binding sites

LMO · dodecyl 6-O-alpha-D-galactopyranosyl-beta-D-glucopyranoside · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1171	0.83	0.83	69	LMO
2	120	0.67	0.89	25	empty

Compared structures

7L16 · Crystal structure of sugar-bound melibiose permease MelB · the same entry in another collection · chain A against A, TM-score 1.00
P30878 · AlphaFold monomer V2.0 prediction for melibiose carrier protein (P30878) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30878
Elsewhere: RCSB PDB 7L16 · PDBe 7L16 · UniProt P30878

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