Research workbench
Monobody 12VC1 bound to HRAS(G12C)
Analyse Monobody 12VC1 bound to HRAS(G12C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7L0G
- Type
- protein
- Length
- 1,034 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTPase HRAS; Monobody 12VC1
- EC
- 3.6.5.2
- UniProt
- P01112
- Ligands
- GSP, MG
- Pockets
- 12 · best druggability 0.88
Structure
x-ray diffraction · 4 distinct chains · 24% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, G | GTPase HRAS (EC 3.6.5.2) | protein | 166 | 37% helix, 27% strand | P01112 |
| C, D, F | Monobody 12VC1 | protein | 93 | 0% helix, 55% strand | — |
| E | GTPase HRAS (EC 3.6.5.2) | protein | 165 | 37% helix, 25% strand | P01112 |
| H | Monobody 12VC1 | protein | 92 | 0% helix, 58% strand | — |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · 4 copies · chains A, C, B, D, E, F, G, H
- MG · Magnesium ion · metal · 4 copies · chains A, B, E, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1061 | 0.88 | 0.90 | 130 | GSP, MG |
| 2 | 728 | 0.77 | 0.82 | 78 | GSP, MG |
| 3 | 302 | 0.72 | 0.85 | 52 | GSP, MG |
| 4 | 387 | 0.70 | 0.82 | 66 | empty |
| 5 | 247 | 0.70 | 0.86 | 46 | GSP, MG |
Interfaces
12 interfaces between chains.
- A–C · 924 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 909 Ų buried · 14 hydrogen bonds · protein-protein
- G–H · 896 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 893 Ų buried · 11 hydrogen bonds · protein-protein
- B–G · 791 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7L0G · Monobody 12VC1 Bound to HRAS(G12C) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01112
- Elsewhere: RCSB PDB 7L0G · PDBe 7L0G · UniProt P01112
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.